Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
Most Useful Reviews
9
Pain is gone
1 people found this helpful
Having suffered from herpes zoster, I experienced throbbing nerve pains. Since switching to this B12 neuronutrient, the pain has vanished!
Read More
0
Unfavourable ingredients
4 people found this helpful
After taking it, I feel uncomfortable, and my bones and joints hurt. I suspect that there are unfavourable ingredients in it and I am hesitant to repurchase.
Read More
9
Pains are gone
1 people found this helpful
After two weeks of taking this alongside a women's complex, I feel better! The pains during my menstrual cycle have disappeared!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain is gone
1 people found this helpful
Having suffered from herpes zoster, I experienced throbbing nerve pains. Since switching to this B12 neuronutrient, the pain has vanished!
Read More
0
Unfavourable ingredients
4 people found this helpful
After taking it, I feel uncomfortable, and my bones and joints hurt. I suspect that there are unfavourable ingredients in it and I am hesitant to repurchase.
Read More
9
Pains are gone
1 people found this helpful
After two weeks of taking this alongside a women's complex, I feel better! The pains during my menstrual cycle have disappeared!
Read More
9
Foot pain relief
1 people found this helpful
My mother struggled with foot pain until a friend suggested she try this B12. The pain has subsided, and it also benefits her eyes and combats fatigue. The ingredients are safe, and the packaging is excellent.
Read More
7.5
Joint pain relief
1 people found this helpful
I stopped eating meat in August due to my blood type and neglected my B12. Two weeks ago, I started experiencing joint pain and other issues. I realised it was due to a B12 deficiency. These supplements work effectively, allowing me to resume my fitness routine. Folate is also beneficial.
Read More
Frequently Asked Questions
9
Pains are gone
1 people found this helpful
After two weeks of taking this alongside a women's complex, I feel better! The pains during my menstrual cycle have disappeared!
7.5
Joint pain relief
1 people found this helpful
I stopped eating meat in August due to my blood type and neglected my B12. Two weeks ago, I started experiencing joint pain and other issues. I realised it was due to a B12 deficiency. These supplements work effectively, allowing me to resume my fitness routine. Folate is also beneficial.
0
Unfavourable ingredients
4 people found this helpful
After taking it, I feel uncomfortable, and my bones and joints hurt. I suspect that there are unfavourable ingredients in it and I am hesitant to repurchase.
9
Pain is gone
1 people found this helpful
Having suffered from herpes zoster, I experienced throbbing nerve pains. Since switching to this B12 neuronutrient, the pain has vanished!
9
Foot pain relief
1 people found this helpful
My mother struggled with foot pain until a friend suggested she try this B12. The pain has subsided, and it also benefits her eyes and combats fatigue. The ingredients are safe, and the packaging is excellent.
7.5
No body pains
5 people found this helpful
I recommend important vitamins to enhance my health. I no longer feel the lethargy I used to experience and have no body pains upon waking. It is vital that these last for three months, and I wish you good luck! ❤️
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
References
- Gu YJ, Qian HY, Zhou F, Zhang L, Chen L, et al. Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats. Brain Res. 2023;1811:148405. 10.1016/j.brainres.2023.148405
- Fathi Maroufi N, Ghorbanihaghjo A, Sayyah Melli M, Vaezi M, Hekmati Azar Mehrabani Z, et al. Effects of High and Low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-kappa B Ligand/Osteoprotegerin Ratio during Pregnancy. Iran J Public Health. 2017;46:517.
